【Abstract】 Objective To learn the resistance situation of Musca domestica from different areas in Hubei province to common insecticides and study its control measures.  Methods Topical application was used in this study.  Results The surveillance results indicated the average LD50 values of DDVP to housefly from different areas was 0.2256, 0.1908 and 0.4428 μg/housefly from 2005 to 2007, respectively. The average LD50 of alpha?cypermethrin was 0.0841 and 0.1102 μg/housefly in 2006 and 2007, respectively. The average LD50 of deltamethrin was 0.0371 and 0.0825 μg/housefly in 2005 and 2007, respectively. The average LD50 of etramethrin in 2005 and 2006 was 0.3952 and 0.2894 μg/housefly, respectively. The average LD50 of acetophenate in 2005 and 2007 was 0.3264 and 0. 3487 μg/housefly. Conclusion M.domestica had high resistance to organic phosphorus and pyrethrum insecticide in Hubei province. No obvious resistance against acetophenate had been found. The mixed and rotation use of insecticides contributed to the control the resistance development of M.domestica.

Objective To study the resistant development of Rattus norvegicus to anticoagulant rodenticide after its application in Qichun county.Methods The resistance of R.norvegicus was tested according to the method established by Rodenticide-resistance Monitoring Cooperation Group of China.Results The resistance of R.norvegicus was detected in 1990,1995,2000,2002,2005 and 2007,respectively.There were 208 rodents tested,and only one rodent survived in each of three times resistance monitoring.Whether the test rodent were male or female,the minimum and maximum average lethal dosages in 2000-2008 resistance monitoring was all lower than that in 1995.But the average lethal time postponed a little compared to that in 1990.Conclusion After the application of anticoagulant rodenticide for 23 years in Qichun, R.norvegicus was still highly susceptible to the first-generation anticoagulant rodenticides,and its tolerance capability was lower than that of R.tanezumi and Mus musculus.Therefore,the anticoagulant rodenticides could be still used to kill R.norvegicus.

Objective To evaluate diseases prevention and control in the reservoir before the sluicing,and to understand the morbidity level and trend of zoonosis in the population in the Three Gorges Area after the sluicing.Methods The standard disinfection and vector control practises issued by China CDC,to analysis the data of zoonosis in Three Gorges area.Results After the clearance of waste out of the reservoir before the slucing,no outbreak of Epidemic Hemorrhagic Fever,leptospirosis and Encephalitis B is reported.Conclusion Waste clearance can protect the water from being polluted after the sluicing,no outbreak of zoonosis-borne diseases is reported,and no significant effect of environment change on the zoonnosis is found.

Objective To investigate the change of the density of rodents before and after the 2nd phase water storage in Three Gorges reservoir. Methods Mousetraps were used to detect the density of rodents in different periods,and Bromadiolone was applied in large area before water storage. Results The indoor density of rodents before water storage is 4.07%,while it is 3.17% after water storage;the outdoor density of rodents before water storage is 3.17%,and it is 2.35% after water storage. Conclusion The density of rodents in Three Gorges reservoir before and after the 2nd phase water storage do not change greatly.

Objective:To study the resistance and different effect of anticoaglant rodenticide.Methods:Tests of optional and nonoptional taking food.Results:Resistance of three commensal rodent species was not difference for the ten years in Qichun.However,average rate lethal dose of pure drug to tested rodent was obvious drop,average lethal dates were prolong.Killed rate of four anticoagalant rodenticides to Rattus norvegicus was up to 91%,Taking food coefficient at single coop and crovd fence for coumatetralyl were 0.85 and 1.58 respectively;for Bromodiolone were 0.76 and 0.69 respectively,for warfarin were 0.38 and 0.31,for Diphacine Sodium Sait were 0.35 and 0.25.Conclusion:Two tests of anticoagalant shewed that the anticogalant susceptibility for the three species commensal rodent was high in Qichun,and resistance was not happened.The killed rate of the four rodenticide to Rattus norvegicus was high,and the palatable taste of coumatetpalyl was the best in the four species rodicide.

A field trial lasting for 2 years was carried out through setting up three areas,plain area (control), rodenticide area (control), and test area in Tianmen, Hubei to explore the way.ofcommensal rodent management in residential quarters of urban areas.The results showed that applying integrated management with ecological measures playing a leading role could achieve a similar or even better effect than using rodenticides against commensal rodents,not only to bring therodent problem under control,but also to abate or avoid the side effects and defects of the lattersuch as environmental pollution,poisoning by mistaken feed or secondary poisoning,a shorter duration of effect,rodenticide tolerance and resistance and consuming a great deal of manpower,monetory means and material resources,etc.